Owen Milgrim (Jonah Hill) suffers from Schizophrenia, which has left him on the outer edges of his wealthy family. His only hope of redeeming himself is by agreeing to provide an alibi for his brother Jed (Billy Magnussen) in a court case against him that could potentially ruin the family business. After losing his job and unwilling to take assistance from his parents, Owen decides to participate in a mysterious medical trial to make some money.

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